Which corticosteroid is least effective in treating anterior uveitis?

Which corticosteroid is least effective in treating anterior uveitis?

• A. Lotemax
• B. FML
• C. Pred Forte
• D. Rimexolone

Answer: (B)

The main idea is that potency and tissue penetration of topical corticosteroids determine how well they control anterior uveitis. Fluorometholone is the least potent among the options listed, so its ability to suppress intraocular inflammation—cells and flare in the anterior chamber—tends to be weaker and slower than with the other steroids. That makes it the least effective choice for actively inflamed anterior uveitis. In contrast, prednisolone acetate is a high-potency steroid used for aggressive inflammation, rimexolone offers solid anterior segment penetration with intermediate-to-high potency, and loteprednol provides effective control with a safety emphasis (soft steroid design and lower risk of IOP rise). So, while fluorometholone has advantages in safety, its weaker anti-inflammatory effect is the reason it’s less effective for treating active anterior uveitis.

The main idea is that potency and tissue penetration of topical corticosteroids determine how well they control anterior uveitis. Fluorometholone is the least potent among the options listed, so its ability to suppress intraocular inflammation—cells and flare in the anterior chamber—tends to be weaker and slower than with the other steroids. That makes it the least effective choice for actively inflamed anterior uveitis.

In contrast, prednisolone acetate is a high-potency steroid used for aggressive inflammation, rimexolone offers solid anterior segment penetration with intermediate-to-high potency, and loteprednol provides effective control with a safety emphasis (soft steroid design and lower risk of IOP rise). So, while fluorometholone has advantages in safety, its weaker anti-inflammatory effect is the reason it’s less effective for treating active anterior uveitis.